Cd1d1 - CD1d1 antigen Gene

Also Known as Cd1a; Cd1d; CD1.1; Ly-38

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12479

Summary

Enables T cell receptor binding activity and endogenous lipid antigen binding activity. Involved in NK T cell differentiation and regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including antigen processing and presentation, exogenous lipid antigen via MHC class Ib; positive regulation of cytokine production; and positive regulation of leukocyte activation. Located in endosome; external side of plasma membrane; and lysosome. Is expressed in forebrain; intestine; jaw bone; and liver. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human CD1d (CD1d molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd1d1 Products (13)

mRNA Protein Name
NM_001379501.1 NP_001366430.1 antigen-presenting glycoprotein CD1d1 isoform 2 precursor
NM_001379502.1 NP_001366431.1 antigen-presenting glycoprotein CD1d1 isoform 3 precursor
NM_001379503.1 NP_001366432.1 antigen-presenting glycoprotein CD1d1 isoform 4
NM_001409614.1 NP_001396543.1 antigen-presenting glycoprotein CD1d1 isoform 5 precursor
NM_001409615.1 NP_001396544.1 antigen-presenting glycoprotein CD1d1 isoform 1 precursor
NM_001409616.1 NP_001396545.1 antigen-presenting glycoprotein CD1d1 isoform 4
NM_001409617.1 NP_001396546.1 antigen-presenting glycoprotein CD1d1 isoform 4
NM_001409618.1 NP_001396547.1 antigen-presenting glycoprotein CD1d1 isoform 4
NM_001409619.1 NP_001396548.1 antigen-presenting glycoprotein CD1d1 isoform 6
NM_001409620.1 NP_001396549.1 antigen-presenting glycoprotein CD1d1 isoform 8
NM_001409621.1 NP_001396550.1 antigen-presenting glycoprotein CD1d1 isoform 9 precursor
NM_001409622.1 NP_001396551.1 antigen-presenting glycoprotein CD1d1 isoform 7 precursor
NM_007639.4 NP_031665.2 antigen-presenting glycoprotein CD1d1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables T cell receptor binding IDA
IDA: Inferred from direct assay
22065767 MGI
enables endogenous lipid antigen binding IDA
IDA: Inferred from direct assay
14722359 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11754812 MGI
Biological Process GO Annotation Evidence References Source
involved in NK T cell differentiation IMP
IMP: Inferred from mutant phenotype
9133426 MGI
acts upstream of or within antigen processing and presentation IDA
IDA: Inferred from direct assay
11754812 MGI
acts upstream of or within antigen processing and presentation, exogenous lipid antigen via MHC class Ib IDA
IDA: Inferred from direct assay
14557411 MGI
acts upstream of or within positive regulation of NK T cell activation IDA
IDA: Inferred from direct assay
7538697 MGI
acts upstream of or within positive regulation of NK T cell differentiation IMP
IMP: Inferred from mutant phenotype
9133426 MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
10201995 MGI
acts upstream of or within positive regulation of interleukin-2 production IDA
IDA: Inferred from direct assay
7538697 MGI
acts upstream of or within positive regulation of interleukin-4 production IDA
IDA: Inferred from direct assay
7538697 MGI
acts upstream of or within positive regulation of interleukin-4 production IMP
IMP: Inferred from mutant phenotype
9133426 MGI
acts upstream of or within positive regulation of macrophage activation IDA
IDA: Inferred from direct assay
21460847 MGI
acts upstream of or within positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
9133426 MGI
acts upstream of or within positive thymic T cell selection IMP
IMP: Inferred from mutant phenotype
9133426 MGI
involved in regulation of immature T cell proliferation in thymus IMP
IMP: Inferred from mutant phenotype
11550008 MGI
acts upstream of or within regulation of immune response IMP
IMP: Inferred from mutant phenotype
9133426 MGI
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
11754812 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9133426 MGI
located in late endosome IDA
IDA: Inferred from direct assay
11754812 MGI
located in lysosome IDA
IDA: Inferred from direct assay
11754812 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

antigen-presenting glycoprotein CD1d1

  • T-cell surface glycoprotein CD1d1

Recombinant Cd1d1 Proteins

Cat. No. Product Name Accession Purity
HY-P75436 CD1D Protein, Mouse (HEK293, His-Fc) P11609 (M1-G305) ≥ 80%, as determined by reducing SDS-PAGE.
HY-P75437 CD1D Protein, Mouse (HEK293, His) P11609 (M1-G305) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76778 CD1D1-B2M Heterodimer Protein, Mouse (HEK293, His) P11609 (Q22-W297)&P01887 (I21-M119) ≥ 95%, as determined by reducing SDS-PAGE.